Synthesis and Anticancer Activity of Podophyllotoxin Derivatives
نویسندگان
چکیده
Two series of podophyllotoxin derivatives were synthesized by addition a 4?-sulfanilamide to or substitution 4?-amide into podophyllotoxin. Their cytotoxicities evaluated against four human cancer cell lines (A549, HeLa, MCF-7, and PC-3). Investigations the structure–activity relationship generalized. Derivative 9f (2-thienoylaminoepipodophyllotoxin) exhibited highest activity cells, inhibiting growth MCF-7 cells with IC50 0.67 ± 0.37 ?M. A change in morphology treated also confirmed its as cytotoxic derivative cells.
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ژورنال
عنوان ژورنال: Chemistry of Natural Compounds
سال: 2021
ISSN: ['1573-8388', '0009-3130']
DOI: https://doi.org/10.1007/s10600-021-03539-z